Sex-biased Immune Responses Following SARS-CoV-2 Infection

Rebecca L Ursin; Janna R Shapiro; Sabra L Klein

doi:10.1016/j.tim.2020.10.002

Sex-biased Immune Responses Following SARS-CoV-2 Infection

Trends Microbiol. 2020 Dec;28(12):952-954. doi: 10.1016/j.tim.2020.10.002. Epub 2020 Oct 10.

Authors

Rebecca L Ursin¹, Janna R Shapiro², Sabra L Klein³

Affiliations

¹ Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
² Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
³ Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: sklein2@jhu.edu.

Abstract

Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).

Keywords: COVID-19; SARS-CoV-2; biological sex; immunopathogenesis.

Publication types

Comment

MeSH terms

Betacoronavirus*
COVID-19
Coronavirus Infections*
Female
Humans
Male
Pandemics*
Pneumonia, Viral*
SARS-CoV-2
Severe Acute Respiratory Syndrome*

Abstract

Publication types

MeSH terms

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