Molecular docking studies, anti-Alzheimer's disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside

Arch Physiol Biochem. 2023 Apr;129(2):405-415. doi: 10.1080/13813455.2020.1828483. Epub 2020 Oct 19.

Abstract

In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside's antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside's radical scavenging activities were evaluated by DPPH and ABTS+ scavenging activities. On the other hand, IC50 values were calculated for DPPH, and ABTS+ scavenging, acetylcholinesterase, and α-glucosidase inhibition effects of narcissoside. IC50 values narcissoside, as 11.54 nM for AChE and 65.58 nM for α-glucosidase were calculated with % Activity-[Inhibitory] graphs. Then, ADME/T analysis of narcissoside molecule was performed to calculate the drug becoming parameters.

Keywords: Narcissoside; acetylcholinesterase; acute myeloid leukaemia; therapeutic activities.

MeSH terms

  • Acetylcholinesterase
  • Alzheimer Disease* / drug therapy
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Cholinesterase Inhibitors / pharmacology
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Leukemia, Myeloid*
  • Molecular Docking Simulation
  • alpha-Glucosidases

Substances

  • Antioxidants
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • Hypoglycemic Agents
  • Cholinesterase Inhibitors
  • alpha-Glucosidases
  • Acetylcholinesterase