The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

Mingxian Chen; Xuping Li; Songyun Wang; Lilei Yu; Jianjun Tang; Shenghua Zhou

doi:10.3389/fphys.2020.01113

The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

Front Physiol. 2020 Sep 23:11:1113. doi: 10.3389/fphys.2020.01113. eCollection 2020.

Authors

Mingxian Chen¹, Xuping Li¹, Songyun Wang², Lilei Yu², Jianjun Tang¹, Shenghua Zhou¹

Affiliations

¹ The Second Xiangya Hospital, Central South University, Changsha, China.
² Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.

Keywords: connexin43; cytokines; electrophysiology; macrophage; ventricular arrhythmias.

Publication types

Review