Lycopene and Melatonin: Antioxidant Compounds in Cosmetic Formulations

Skin Pharmacol Physiol. 2020;33(5):237-243. doi: 10.1159/000508673. Epub 2020 Oct 16.

Abstract

Background: The use of antioxidants has become a common practice in the development of antiaging cosmetics.

Objective: The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants.

Method: Thirty-six healthy women from 32 to 65 years were enrolled in this study. The study was carried out for 10 weeks, 2 preconditioning weeks with a control cream without antioxidants, and 8-week test with creams containing antioxidants in study. A multifunctional skin physiology monitor (Courage & Khazaka electronic GmbH®, Germany) was used to measure skin sebum content, hydration, elasticity, erythema index, and melanin index in 4 different regions of the face.

Results: There were significant differences between them.

Keywords: Antioxidant; Lycopene; Melatonin; Skin aging.

MeSH terms

  • Adult
  • Aged
  • Antioxidants / administration & dosage*
  • Antioxidants / metabolism
  • Cosmetics / administration & dosage*
  • Cosmetics / metabolism
  • Drug Combinations
  • Drug Compounding
  • Female
  • Humans
  • Lycopene / administration & dosage*
  • Lycopene / metabolism
  • Melatonin / administration & dosage*
  • Melatonin / metabolism
  • Middle Aged
  • Skin Aging / drug effects
  • Skin Aging / physiology
  • Skin Cream / administration & dosage*
  • Skin Cream / metabolism
  • Skin Physiological Phenomena / drug effects*

Substances

  • Antioxidants
  • Cosmetics
  • Drug Combinations
  • Melatonin
  • Lycopene