The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - A short revisit

Zhanat Koshenov; Furkan E Oflaz; Martin Hirtl; Olaf A Bachkoenig; Rene Rost; Karin Osibow; Benjamin Gottschalk; Corina T Madreiter-Sokolowski; Markus Waldeck-Weiermair; Roland Malli; Wolfgang F Graier

doi:10.1016/j.mito.2020.10.003

The contribution of uncoupling protein 2 to mitochondrial Ca²⁺ homeostasis in health and disease - A short revisit

Mitochondrion. 2020 Nov:55:164-173. doi: 10.1016/j.mito.2020.10.003. Epub 2020 Oct 15.

Affiliations

¹ Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria.
² Diagnostic and Research Institute for Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria; Department of Health Sciences and Technology, ETH Zurich, Schorenstraße 16, 8603 Schwerzenbach, Switzerland.
³ Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; Diagnostic and Research Institute for Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
⁴ Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
⁵ Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; BioTechMed, Graz, Austria.
⁶ Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria; BioTechMed, Graz, Austria. Electronic address: wolfgang.graier@medunigraz.at.

PMID: 33069910
DOI: 10.1016/j.mito.2020.10.003

Abstract

Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca²⁺) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.

Keywords: MCU; MICU1; Mitochondrial calcium homeostasis; PRMT1; UCP2.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Calcium / metabolism*
HeLa Cells
Homeostasis
Humans
Mitochondria / metabolism*
Mitochondrial Diseases / metabolism*
Uncoupling Protein 2 / metabolism*

Substances

UCP2 protein, human
Uncoupling Protein 2
Calcium