Multimodal medical image fusion via laplacian pyramid and convolutional neural network reconstruction with local gradient energy strategy

Abstract

Background: In recent years, numerous fusion algorithms have been proposed for multimodal medical images. The Laplacian pyramid is one type of multiscale fusion method. Although the pyramid-based fusion algorithm can fuse images well, it has the disadvantages of edge degradation, detail loss and image smoothing as the number of decomposition layers increase, which is harmful for medical diagnosis and analysis.

Method: This paper proposes a medical image fusion algorithm based on the Laplacian pyramid and convolutional neural network reconstruction with local gradient energy strategy, which can greatly improve the edge quality. First, multimodal medical images are reconstructed through convolutional neural network. Then, the Laplacian pyramid is applied in the decomposition and fusion process. The optimal number of decomposition layers is determined by experiments. In addition, a local gradient energy fusion strategy is utilized to fuse the coefficients in each layer. Finally, the fused image is output through Laplacian inverse transformation.

Results: Compared with existing algorithms, our fusion results represent better vision quality performance. Furthermore, our algorithm is considerably superior to the compared algorithms in objective indicators. In addition, in our fusion results of Alzheimer and Glioma, the disease details are much clearer than those of compared algorithms, which can provide a reliable basis for doctors to analyze disease and make pathological diagnoses.

Keywords: Convolutional neural network; Decomposition; Laplacian pyramid; Local gradient energy; Multimodal.