Medical Treatment in Coronary Patients: Is there Still a Gender Gap? Results from European Society of Cardiology EUROASPIRE V Registry

Cardiovasc Drugs Ther. 2021 Aug;35(4):801-808. doi: 10.1007/s10557-020-07095-6. Epub 2020 Oct 17.

Abstract

Purpose: This study is aimed at investigating gender differences in the medical management of patients with coronary heart disease (CHD).

Methods: Analyses were based on the ESC EORP EUROASPIRE V (European Survey Of Cardiovascular Disease Prevention And Diabetes) survey. Consecutive patients between 18 and 80 years, hospitalized for a coronary event, were included in the study. Information on cardiovascular medication intake at hospital discharge and at follow-up (≥ 6 months to < 2 years after hospitalization) was collected.

Results: Data was available for 8261 patients (25.8% women). Overall, no gender differences were observed in the prescription and use of cardioprotective medication like aspirin, beta-blockers, and ACE-I/ARBs (P > 0.01) at discharge and follow-up respectively. However, a statistically significant difference was found in the use of statins at follow-up, in disfavor of women (82.8% vs. 77.7%; P < 0.001). In contrast, at follow-up, women were more likely to use diuretics (31.5% vs. 39.5%; P < 0.001) and calcium channel blockers (21.2% vs. 28.8%; P < 0.001), whereas men were more likely to use anticoagulants (8.8% vs. 7.0%; P < 0.001). Overall, no gender differences were found in total daily dose intake (P > 0.01). Furthermore, women were less likely than men to have received a CABG (20.4% vs. 13.2%; P < 0.001) or PCI (82.1% vs. 74.9%; P < 0.001) at follow-up. No gender differences were observed in prescribed (P = 0.10) and attended (P = 0.63) cardiac rehabilitation programs.

Conclusion: The EUROASPIRE V results show only limited gender differences in the medical management of CHD patients. Current findings suggest growing awareness about risk in female CHD patients.

Keywords: Cardiovascular diseases; EUROASPIRE; Gender; Medical treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiac Rehabilitation / statistics & numerical data*
  • Cardiovascular Agents* / classification
  • Cardiovascular Agents* / therapeutic use
  • Coronary Artery Bypass / statistics & numerical data*
  • Coronary Disease* / drug therapy
  • Coronary Disease* / epidemiology
  • Coronary Disease* / prevention & control
  • Europe / epidemiology
  • Female
  • Health Knowledge, Attitudes, Practice
  • Hospitalization / statistics & numerical data
  • Humans
  • Middle Aged
  • Patient Care Management / methods
  • Patient Care Management / statistics & numerical data
  • Practice Patterns, Physicians'
  • Secondary Prevention / methods
  • Sex Factors
  • Women's Health

Substances

  • Cardiovascular Agents