The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function

Linglan Fang; Dustin J Maly

doi:10.1016/j.chembiol.2020.09.007

The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function

Cell Chem Biol. 2020 Oct 15;27(10):1221-1223. doi: 10.1016/j.chembiol.2020.09.007.

Authors

Linglan Fang¹, Dustin J Maly²

Affiliations

¹ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
² Department of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: djmaly@uw.edu.

PMID: 33065025
DOI: 10.1016/j.chembiol.2020.09.007

Abstract

Cell permeable, small molecule inhibitors are powerful tools for interrogating kinase function and validating drug targets. In this issue of Cell Chemical Biology, Liu and colleagues (2020) describe the development of a toolkit containing a highly selective DCLK1 inhibitor and complementary DCLK1 mutants for interrogating DCLK1-dependent cellular processes.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Biology
Protein Serine-Threonine Kinases* / genetics
Protein Serine-Threonine Kinases* / metabolism
RNA Processing, Post-Transcriptional*

Substances

Protein Serine-Threonine Kinases

Grants and funding

R01 GM086858/GM/NIGMS NIH HHS/United States