Abstract
Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.
Keywords:
low-grade glioma; retinoblastoma; second cancers; survivorship.
© 2020 Wiley Periodicals LLC.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Adolescent
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Cerebellum / pathology
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Female
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Genetic Predisposition to Disease / genetics
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Glioma / genetics*
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Glioma / pathology
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Humans
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Male
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Neoplasms, Second Primary / diagnosis
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Neoplasms, Second Primary / genetics*
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Retinal Neoplasms / genetics*
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Retinal Neoplasms / pathology
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Retinal Neoplasms / therapy
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Retinoblastoma / genetics*
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Retinoblastoma / pathology
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Retinoblastoma / therapy
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Retinoblastoma Binding Proteins / genetics*
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Temporal Lobe / pathology
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Ubiquitin-Protein Ligases / genetics*
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Young Adult
Substances
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RB1 protein, human
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Retinoblastoma Binding Proteins
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Ubiquitin-Protein Ligases