Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital - A Retrospective Analysis

Zoltán Tóth; Balázs Szalay; Béla Gyarmati; Dlovan Ali Jalal; Barna Vásárhelyi; Tamás Szabó

Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital - A Retrospective Analysis

EJIFCC. 2020 Sep 29;31(3):225-230. eCollection 2020 Sep.

Authors

Zoltán Tóth¹, Balázs Szalay², Béla Gyarmati³, Dlovan Ali Jalal², Barna Vásárhelyi^{2

4}, Tamás Szabó²

Affiliations

¹ Department of Urology, Uzsoki Hospital, Budapest, Hungary.
² Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
³ Department of Gyneocology and Obstetrics, Uzsoki Hospital, Budapest, Hungary.
⁴ Hungarian Academy of Sciences, Budapest, Hungary.

PMID: 33061877
PMCID: PMC7545131

Abstract

Background: Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels.

Methods: From our laboratory database we selected 5136 male patients with simultaneously determined vitamin D and PSA levels. Subgroups of several age cohorts with different vitamin D levels were created and PSA 95 percentile values were assessed. The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression.

Results: PSA levels increased with age, while no difference was identified in PSA levels in different vitamin D subgroups.

Conclusion: Vitamin D levels do not have an effect on PSA. Hence, there is no need to adjust PSA reference ranges and threshold values to vitamin D levels during the process of decision making.

Keywords: age cohort reference values; prostate specific antigen; vitamin-D levels.