Progress in Research on Colorectal Cancer-Related Microorganisms and Metabolites

Shuwen Han; Jing Zhuang; Yinhang Wu; Wei Wu; Xi Yang

doi:10.2147/CMAR.S268943

Progress in Research on Colorectal Cancer-Related Microorganisms and Metabolites

Cancer Manag Res. 2020 Sep 21:12:8703-8720. doi: 10.2147/CMAR.S268943. eCollection 2020.

Authors

Shuwen Han¹, Jing Zhuang², Yinhang Wu³, Wei Wu⁴, Xi Yang¹

Affiliations

¹ Department of Oncology, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, Huzhou 313000, People's Republic of China.
² Graduate School of Nursing, Huzhou University, Huzhou 313000, People's Republic of China.
³ Graduate School of Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Hangzhou 310053, People's Republic of China.
⁴ Department of Gastroenterology, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, Huzhou 313000, People's Republic of China.

Abstract

Intestinal flora is an important component in the human body, which have been reported to be involved in the occurrence and development of colorectal cancer (CRC). Indeed, changes in the intestinal flora in CRC patients compared to those in control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. In this review, we summarize the current knowledge on the potential links between the intestinal microbiota and CRC. We illustrated the mechanisms by which intestinal flora imbalance affects CRC, mainly focusing on inflammation, microbial metabolites, and specific bacteria species. In addition, we discuss how a diet exhibits a strong impact on microbial composition and provides risks for developing CRC. Finally, we describe the potential future directions that are based on intestinal microbiota manipulation for CRC diagnosis and treatment.

Keywords: colorectal cancer; diet; inflammation; intestinal flora; microbial metabolites.

Publication types

Review

Grants and funding

This work was supported by the Major Science and Technology Projects for Medical and Health Care of Zhejiang Province (No.WKJ-ZJ-2013), Public Welfare Technology Application Research Program of Huzhou(2019GZB01) Key Research and Development Project of Huzhou Emergency Science and Technology Plan Program of 2020ZDT2015).