Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review

Yayun Xu; Feihu Chen

doi:10.2147/JIR.S273446

Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review

J Inflamm Res. 2020 Sep 28:13:607-617. doi: 10.2147/JIR.S273446. eCollection 2020.

Authors

Yayun Xu^{1

2

3}, Feihu Chen^{1

2

3}

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
² The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
³ The Key Laboratory of Anti-Inflammatory and Immune Medicines, Ministry of Education, Hefei, People's Republic of China.

Abstract

Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

Keywords: anorexigenic; anti-apoptotic; anti-inflammatory; antioxidant; nesfatin-1.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant number 81873986).