On-Site Therapeutic Drug Monitoring

H Ceren Ates; Jason A Roberts; Jeffrey Lipman; Anthony E G Cass; Gerald A Urban; Can Dincer

doi:10.1016/j.tibtech.2020.03.001

On-Site Therapeutic Drug Monitoring

Trends Biotechnol. 2020 Nov;38(11):1262-1277. doi: 10.1016/j.tibtech.2020.03.001. Epub 2020 Apr 2.

Authors

H Ceren Ates¹, Jason A Roberts², Jeffrey Lipman³, Anthony E G Cass⁴, Gerald A Urban⁵, Can Dincer⁶

Affiliations

¹ Freiburg Centre for Interactive Materials and Bioinspired Technologies - FIT, University of Freiburg, 79110 Freiburg, Germany; Department of Microsystems Engineering - IMTEK, Laboratory for Sensors, University of Freiburg, 79110 Freiburg, Germany.
² Centre of Clinical Research, Faculty of Medicine, The University of Queensland, 4072, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, 4029, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, 4029, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, 4102, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, University of Montpellier, Nîmes University Hospital, 34090, Nîmes, France.
³ Centre of Clinical Research, Faculty of Medicine, The University of Queensland, 4072, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, 4029, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, University of Montpellier, Nîmes University Hospital, 34090, Nîmes, France.
⁴ Department of Chemistry and Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, London, UK.
⁵ Freiburg Centre for Interactive Materials and Bioinspired Technologies - FIT, University of Freiburg, 79110 Freiburg, Germany; Freiburg Materials Research Centre - FMF, University of Freiburg, 79104 Freiburg, Germany.
⁶ Freiburg Centre for Interactive Materials and Bioinspired Technologies - FIT, University of Freiburg, 79110 Freiburg, Germany; Department of Microsystems Engineering - IMTEK, Laboratory for Sensors, University of Freiburg, 79110 Freiburg, Germany. Electronic address: dincer@imtek.dedincer@imtek.de.

PMID: 33058758
DOI: 10.1016/j.tibtech.2020.03.001

Abstract

Recent technological advances have stimulated efforts to bring personalized medicine into practice. Yet, traditional application fields like therapeutic drug monitoring (TDM) have remained rather under-appreciated. Owing to clear dose-response relationships, TDM could improve patient outcomes and reduce healthcare costs. While chromatography-based routine practices are restricted due to high costs and turnaround times, biosensors overcome these limitations by offering on-site analysis. Nevertheless, sensor-based approaches have yet to break through for clinical TDM applications, due to the gap between scientific and clinical communities. We provide a critical overview of current TDM practices, followed by a TDM guideline to establish a common ground across disciplines. Finally, we discuss how the translation of sensor systems for TDM can be facilitated, by highlighting the challenges and opportunities.

Keywords: PK/PD models; biosensors; immunoassays; on-site drug monitoring; pharmacokinetics; wearables.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques*
Drug Monitoring* / instrumentation
Drug Monitoring* / methods
Humans
Precision Medicine

Grants and funding

II-LA-0313-20004/DH_/Department of Health/United Kingdom