Rational Control of Self-Recognition of Macroionic γ-Cyclodextrin by Host-Guest Interaction with Super-Chaotropic Borate Cluster Ions

Jiahui Chen; Jiancheng Luo; Selemon Bekele; Mesfin Tsige; Tianbo Liu

doi:10.1002/cplu.202000536

Rational Control of Self-Recognition of Macroionic γ-Cyclodextrin by Host-Guest Interaction with Super-Chaotropic Borate Cluster Ions

Chempluschem. 2020 Oct;85(10):2316-2319. doi: 10.1002/cplu.202000536.

Authors

Jiahui Chen¹, Jiancheng Luo¹, Selemon Bekele¹, Mesfin Tsige¹, Tianbo Liu¹

Affiliation

¹ School of Polymer Science and Engineering, The University of Akron, 44325, Akron, OH, USA.

PMID: 33058510
DOI: 10.1002/cplu.202000536

Abstract

We report a feasible method to control self-recognition during the self-assembly of a hydrophilic macroion, phosphate-functionalized γ-cyclodextrin (γ-CD-P), though host-guest interactions. We confirmed that γ-CD-P can form a host-guest complex with a super-chaotropic anion, namely the B₁₂ F₁₂^2- borate cluster, by using NMR spectroscopy and isothermal titration calorimetry. The loaded γ-CD-P, which has a higher charge density, can be distinguished from the uncomplexed γ-CD-P, leading to self-sorting behavior during the self-assembly process, confirmed by the formation of two types of individual supramolecular structures (R_h of ca. 57 nm and 18 nm, determined by light scattering) instead of hybrid structures in mixed dilute solution. This self-recognition behavior is accounted for by the difference in intermolecular electrostatic interactions arising from the loading.

Keywords: borate clusters; cyclodextrins; host-guest systems; self-assembly; self-recognition.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.