A review of UMAP in population genetics

J Hum Genet. 2021 Jan;66(1):85-91. doi: 10.1038/s10038-020-00851-4. Epub 2020 Oct 14.

Abstract

Uniform manifold approximation and projection (UMAP) has been rapidly adopted by the population genetics community to study population structure. It has become common in visualizing the ancestral composition of human genetic datasets, as well as searching for unique clusters of data, and for identifying geographic patterns. Here we give an overview of applications of UMAP in population genetics, provide recommendations for best practices, and offer insights on optimal uses for the technique.

Publication types

  • Review

MeSH terms

  • Computational Biology / methods*
  • Gene Frequency
  • Genetic Variation*
  • Genetics, Population / methods*
  • Genome, Human / genetics*
  • Genomics / methods*
  • Genotype
  • HLA Antigens / genetics
  • Human Genome Project
  • Humans

Substances

  • HLA Antigens