No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma

Shin Yeu Ong; Jing Quan Lim; Nicholas Grigoropoulos; Yurike Laurensia; Dachuan Huang; Burton Kuan Hui Chia; Daryl Cheah Ming Zhe; Sahil Ajit Saraf; Chee Leong Cheng; Wen-Yu Chuang; Ming-Chung Kuo; Yi-Jiun Su; Colin Phipps; Chandramouli Nagarajan; Yuh Shan Lee; Daryl Tan Chen Lung; Lee-Yung Shih; Yeow Tee Goh; Soon Thye Lim; Choon Kiat Ong

doi:10.3324/haematol.2020.269209

No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma

Haematologica. 2021 Jun 1;106(6):1737-1739. doi: 10.3324/haematol.2020.269209.

Authors

Shin Yeu Ong¹, Jing Quan Lim², Nicholas Grigoropoulos¹, Yurike Laurensia³, Dachuan Huang², Burton Kuan Hui Chia³, Daryl Cheah Ming Zhe³, Sahil Ajit Saraf⁴, Chee Leong Cheng⁴, Wen-Yu Chuang⁵, Ming-Chung Kuo⁶, Yi-Jiun Su⁶, Colin Phipps¹, Chandramouli Nagarajan¹, Yuh Shan Lee¹, Daryl Tan Chen Lung¹, Lee-Yung Shih⁶, Yeow Tee Goh¹, Soon Thye Lim⁷, Choon Kiat Ong⁸

Affiliations

¹ Department of Haematology, Singapore General Hospital.
² National Cancer Center, Singapore; Duke-NUS Medical School.
³ National Cancer Center.
⁴ Department of Pathology, Singapore General Hospital.
⁵ Department of Pathology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan.
⁶ Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan.
⁷ National Cancer Center, Singapore; Duke-NUS Medical School. lim.soon.thye@singhealth.com.sg.
⁸ National Cancer Center, Singapore; Duke-NUS Medical School, Singapore; Genome Institute of Singapore, A*STAR. cmrock@nccs.com.sg.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Germ-Line Mutation*
Humans
Killer Cells, Natural
Lymphohistiocytosis, Hemophagocytic* / diagnosis
Lymphohistiocytosis, Hemophagocytic* / genetics
Lymphoma, T-Cell*
Natural Killer T-Cells*

Substances

Adaptor Proteins, Signal Transducing
Ecsit protein, human

Grants and funding

Funding: the study was supported by grants from the Singapore Ministry of Health’s National Medical Research Council (NMRC-OFLCG-18May0028 and NMRC-ORIRG16nov090), Tanoto Foundation Professorship in Medical Oncology, New Century International Pte Ltd, Ling Foundation, and Chang Gung Memorial Hospital (OMRPG3C0021), Taiwan.