An autonomous wearable system for diurnal sweat biomarker data acquisition

Hannaneh Hojaiji; Yichao Zhao; Max C Gong; Mudith Mallajosyula; Jiawei Tan; Haisong Lin; Amir M Hojaiji; Shuyu Lin; Carlos Milla; Asad M Madni; Sam Emaminejad

doi:10.1039/d0lc00820f

An autonomous wearable system for diurnal sweat biomarker data acquisition

Lab Chip. 2020 Dec 15;20(24):4582-4591. doi: 10.1039/d0lc00820f.

Authors

Affiliations

¹ Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. emaminejad@ucla.edu and Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA.
² Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. emaminejad@ucla.edu and Department of Materials Science and Engineering, University of California, Los Angeles, CA, USA.
³ Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. emaminejad@ucla.edu and Department of Computer Science and Engineering, University of California, Los Angeles, CA, USA.
⁴ Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. emaminejad@ucla.edu.
⁵ The Stanford Cystic Fibrosis Center, Center for Excellence in Pulmonary Biology, Stanford School of Medicine, Stanford, CA, USA.
⁶ Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA.
⁷ Interconnected and Integrated Bioelectronics Lab (I2BL), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. emaminejad@ucla.edu and Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA and Department of Bioengineering, University of California, Los Angeles, CA, USA.

PMID: 33052990
DOI: 10.1039/d0lc00820f

Abstract

To track dynamically varying and physiologically relevant biomarker profiles in sweat, autonomous wearable platforms are required to periodically sample and analyze sweat with minimal or no user intervention. Previously reported sweat sensors are functionally limited to capturing biomarker information at one time-point/period, thereby necessitating repeated user intervention to increase the temporal granularity of biomarker data. Accordingly, we present a compact multi-compartment wearable system, where each compartment can be activated to autonomously induce/modulate sweat secretion (via iontophoretic actuation) and analyze sweat at set time points. This system was developed following a hybrid-flex design and a vertical integration scheme-integrating the required functional modules: miniaturized iontophoresis interfaces, adhesive thin film microfluidic-sensing module, and control/readout electronics. The system was deployed in a human subject study to track the diurnal variation of sweat glucose levels in relation to the daily food intake. The demonstrated autonomous operation for diurnal sweat biomarker data acquisition illustrates the system's suitability for large-scale and longitudinal personal health monitoring applications.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biomarkers
Biosensing Techniques*
Humans
Iontophoresis
Microfluidics
Sweat
Wearable Electronic Devices*

Substances

Biomarkers