We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.
Keywords: HIV; cryptococcal meningitis; mortality; outcome; susceptibility testing.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.