What was First, Obesity or Inflammatory Bowel Disease? What Does the Gut Microbiota Have to Do with It?

Sara Jarmakiewicz-Czaja; Aneta Sokal; Rafał Filip

doi:10.3390/nu12103073

What was First, Obesity or Inflammatory Bowel Disease? What Does the Gut Microbiota Have to Do with It?

Nutrients. 2020 Oct 8;12(10):3073. doi: 10.3390/nu12103073.

Authors

Sara Jarmakiewicz-Czaja¹, Aneta Sokal¹, Rafał Filip^{2

3}

Affiliations

¹ Medical College of Rzeszow University, Institute of Health Sciences, 35-959 Rzeszow, Poland.
² Medical College of Rzeszow University, Institute of Medicine, 35-959 Rzeszow, Poland.
³ Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, 35-301 Rzeszow, Poland.

Abstract

A sedentary lifestyle and inadequate nutrition often leads to disturbances in intestinal homeostasis, which may predispose people to excess body weight and metabolic syndrome. Obesity is frequently observed in patients with inflammatory bowel diseases (IBD), similar to the general population. Obesity may exert a negative effect on the course of IBD as well as reduce the response to treatment. Moreover, it may also be an additional risk factor for vein thromboembolism during the flare. In both obesity and IBD, it is of great importance to implement proper dietary ingredients that exert desirable effect on gut microbiota. The key to reducing body mass index (BMI) and alleviating the course of IBD is preserving healthy intestinal microflora.

Keywords: gut microbiota; inflammatory bowel diseases; obesity.

Publication types

Review

MeSH terms

Diet, Healthy
Female
Gastrointestinal Microbiome*
Humans
Inflammatory Bowel Diseases / diet therapy
Inflammatory Bowel Diseases / etiology
Inflammatory Bowel Diseases / microbiology*
Male
Nutritional Physiological Phenomena / physiology*
Obesity / diet therapy
Obesity / etiology
Obesity / microbiology*
Risk Factors
Sedentary Behavior
Venous Thromboembolism / etiology