Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer

Sita Kugel; Sunil R Hingorani

doi:10.1016/j.ccell.2020.09.010

Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer

Cancer Cell. 2020 Oct 12;38(4):443-445. doi: 10.1016/j.ccell.2020.09.010.

Authors

Sita Kugel¹, Sunil R Hingorani²

Affiliations

¹ Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: skugel@fredhutch.org.
² Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: srh@fredhutch.org.

Abstract

Cellular plasticity contributes to intratumoral heterogeneity, metastatic spread, and treatment resistance of cancers. In this issue of Cancer Cell, Gabitova-Cornell et al. identify the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer with agents commonly prescribed to manage heart disease risk.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Differentiation
Cell Plasticity
Cholesterol
Humans
Pancreatic Neoplasms* / drug therapy
Pancreatic Neoplasms* / genetics
Transforming Growth Factor beta

Substances

Transforming Growth Factor beta
Cholesterol

Abstract

Publication types

MeSH terms

Substances

Grants and funding