Worldwide survey on key indicators for public cord blood banking technologies: By the World Marrow Donor Association Cord Blood Working Group

Stem Cells Transl Med. 2021 Feb;10(2):222-229. doi: 10.1002/sctm.20-0246. Epub 2020 Oct 13.

Abstract

The Cord Blood Working Group of the World Marrow Donor Association created a survey for cord blood banks (CBBs) aimed to identify and understand the main technical procedures currently used by public CBBs worldwide regarding cord blood units (CBUs) available for unrelated hematopoietic stem cell transplantation. These technical procedures include CBU collection, (pre-) processing, packaging, testing, storage, and transport. The survey was an online survey created with SurveyGizmo and was completed individually by each CBB at the end of 2017. The information is valuable to transplant centers, CBBs as well as the global industry of public cord blood banking. In general, we can conclude from this survey that the majority of CBBs are up to standard in terms of CBB technologies. Areas of improvement include accreditation, increase standardization in testing, and setting of total nucleated cells thresholds for acceptance of CBU for public use. Furthermore, there is a need for a consensus in the way CBBs operate in term of reservation and release to facilitate a more straightforward access to the therapy.

Keywords: cord blood banks; cord blood units; public cord blood banks; unrelated hematopoietic stem cell transplantation.

MeSH terms

  • Blood Banking* / methods
  • Bone Marrow
  • Cord Blood Stem Cell Transplantation*
  • Fetal Blood
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Quality Control