Liver transplantation in a patient after COVID-19 - Rapid loss of antibodies and prolonged viral RNA shedding

Am J Transplant. 2021 Apr;21(4):1629-1632. doi: 10.1111/ajt.16349. Epub 2020 Nov 2.

Abstract

To date, little is known about the duration and effectiveness of immunity as well as possible adverse late effects after an infection with SARS-CoV-2. Thus it is unclear, when and if liver transplantation can be safely offered to patients who suffered from COVID-19. Here, we report on a successful liver transplantation shortly after convalescence from COVID-19 with subsequent partial seroreversion as well as recurrence and prolonged shedding of viral RNA.

Keywords: T cell biology; clinical research/practice; immunosuppressant; immunosuppression/immune modulation; liver allograft function/dysfunction; liver transplantation/hepatology; organ transplantation in general.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • COVID-19 / complications*
  • COVID-19 / pathology
  • End Stage Liver Disease / surgery*
  • Humans
  • Liver Transplantation*
  • Male
  • Middle Aged
  • RNA, Viral / genetics
  • SARS-CoV-2
  • Severity of Illness Index
  • Virus Shedding*

Substances

  • Antibodies, Viral
  • RNA, Viral

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