Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01422-20. doi: 10.1128/AAC.01422-20. Print 2020 Dec 16.

Abstract

Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

Keywords: diabetes; host-directed therapy; metformin; tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental*
  • Diabetes Mellitus, Type 2* / drug therapy
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Metformin* / pharmacology
  • Metformin* / therapeutic use
  • Mice
  • Mycobacterium tuberculosis*
  • Tuberculosis* / drug therapy

Substances

  • Hypoglycemic Agents
  • Metformin