Role and mechanism of miR-187 in human cancer

Weiwei Peng; Huanhuan Sha; Xun Sun; Renrui Zou; Yue Zhu; Guoren Zhou; Jifeng Feng

Role and mechanism of miR-187 in human cancer

Am J Transl Res. 2020 Sep 15;12(9):4873-4884. eCollection 2020.

Authors

Weiwei Peng¹, Huanhuan Sha¹, Xun Sun¹, Renrui Zou¹, Yue Zhu¹, Guoren Zhou¹, Jifeng Feng¹

Affiliation

¹ The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing, Jiangsu, China.

PMID: 33042395
PMCID: PMC7540151

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs, approximately 22 nucleotides in length, and involved in the post-transcriptional regulation of gene expression. MiRNAs play fundamental roles in many biological processes such as the development and progression of tumors. In this review, we briefly describe the expression of miR-187 in various types of cancer and discuss the role of miR-187 in cancer development and drug resistance. It is also possible to take miR-187 as an important indicator of diagnosis and prognosis of tumors.

Keywords: MiR-187; biological processes; biomarker; cancers; drug resistance; prognosis.

Publication types

Review