The survey of the works, performed during the 11th five-year period in studying general biological regularities of microcirculation, demonstrates certain success in investigations developed in the following directions: functional geometry of the hemo-microcirculatory bed; elaboration of quantitative and qualitative analysis methods of the microcirculatory system elements; functional morphology of the vascular endothelium; experimental analysis of adaptive mechanisms of the microcirculatory bed; clinical-morphological investigations of microcirculation. Formation of structural-functional units, ensuring specialization of microcirculation in organs, forms the base of the functional geometry of the microcirculatory bed. This makes necessary conditions for compartmentalization of some micro-region in an organ and spatial distribution of various liquid media in dependence of certain topology of microvessels. The most perspective ways in development of morphological investigations, concerning the general biological regularities of microcirculation, are discussed.