Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes

Javad Sharifi-Rad; Monica Butnariu; Shahira M Ezzat; Charles Oluwaseun Adetunji; Muhammad Imran; Seyyed Reza Sobhani; Tabussam Tufail; Tahereh Hosseinabadi; Karina Ramírez-Alarcón; Miquel Martorell; Alfred Maroyi; Natália Martins

doi:10.3389/fphar.2020.567518

Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes

Front Pharmacol. 2020 Sep 16:11:567518. doi: 10.3389/fphar.2020.567518. eCollection 2020.

Authors

Affiliations

¹ Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran.
² Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania", Timisoara, Romania.
³ Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
⁴ Pharmacognosy Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October, Dokki, Egypt.
⁵ Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University Iyamho, Auchi, Nigeria.
⁶ Faculty of Allied Health Sciences, University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan.
⁷ Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁸ Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁹ Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepción, Concepción, Chile.
¹⁰ Centre for Healthy Living, University of Concepción, Concepción, Chile.
¹¹ Unidad de Desarrollo Tecnológico, UDT, Universidad de Concepción, Concepción, Chile.
¹² Department of Botany, University of Fort Hare, Alice, South Africa.
¹³ Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁴ Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

Abstract

Mushrooms have a significant role in human diet as functional food and as a nutraceutical resource. The combination of its umami flavor, protein, vitamins, minerals and carbohydrates has meant that mushrooms could be considered a cheap food source for a long time in many countries. Moreover, mushrooms contain an excellent variety of bioactive metabolites that can be successful in both prevention and treatment of various human health hazards. In addition, extracts from medicinal mushrooms and their metabolites have been verified for wound treating with contribution to different mechanisms of the healing process. This review summarizes the nutritional value and composition of mushrooms, ethnobiology and ethnopharmacology, and wound healing potential.

Keywords: bioactive compounds; ethnobiology; ethnopharmacology; mushrooms; wound healing.

Publication types

Review