Toxin-Induced Channelopathies, Neuromuscular Junction Disorders, and Myopathy

Jacqueline Janecek; Hani Kushlaf

doi:10.1016/j.ncl.2020.07.001

Toxin-Induced Channelopathies, Neuromuscular Junction Disorders, and Myopathy

Neurol Clin. 2020 Nov;38(4):765-780. doi: 10.1016/j.ncl.2020.07.001. Epub 2020 Sep 12.

Authors

Jacqueline Janecek¹, Hani Kushlaf²

Affiliations

¹ Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
² Department of Neurology and Rehabilitation Medicine, University of Cincinnati, 260 Stetson Street Suite 2300, Cincinnati, OH 45219, USA; Department of Pathology and Laboratory Medicine, University of Cincinnati, 234 Goodman Street, LMB, Suite 110, Cincinnati, OH 45219, USA. Electronic address: Hani.Kushlaf@uc.edu.

PMID: 33040860
DOI: 10.1016/j.ncl.2020.07.001

Abstract

Channelopathies, neuromuscular junction disorders, and myopathies represent multiple mechanisms by which toxins can affect the peripheral nervous system. These toxins include ciguatoxin, tetrodotoxin, botulinum toxin, metabolic poisons, venomous snake bites, and several medications. These toxins are important to be aware of because they can lead to serious symptoms, disability, or even death, and many can be treated if recognized ear.

Keywords: Botulism; Ciguatera; HMGCR antibody myopathy; Immune checkpoint inhibitor myopathy; Medication-induced myopathy; Tetrodotoxin; Toxin-induced rhabdomyolysis.

Publication types

Review

MeSH terms

Channelopathies / chemically induced*
Humans
Muscular Diseases / chemically induced*
Neuromuscular Junction Diseases / chemically induced*
Neurotoxicity Syndromes / etiology*
Toxins, Biological / adverse effects*

Substances

Toxins, Biological