Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study

BJOG. 2021 May;128(6):1077-1086. doi: 10.1111/1471-0528.16562. Epub 2020 Nov 19.

Abstract

Objective: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV).

Design: Retrospective observational study.

Setting: Grenada.

Population: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible.

Methods: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA.

Main outcome measures: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity.

Results: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%).

Conclusion: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV.

Tweetable abstract: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.

Keywords: Chikungunya; mother-to-child-transmission; neonatal outcomes; pregnancy; pregnancy outcomes; vertical transmission.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Chikungunya Fever* / diagnosis
  • Chikungunya Fever* / epidemiology
  • Chikungunya Fever* / physiopathology
  • Chikungunya Fever* / transmission
  • Chikungunya virus / isolation & purification
  • Delivery, Obstetric* / adverse effects
  • Delivery, Obstetric* / methods
  • Delivery, Obstetric* / statistics & numerical data
  • Disease Outbreaks / statistics & numerical data
  • Female
  • Fetal Distress* / diagnosis
  • Fetal Distress* / etiology
  • Grenada / epidemiology
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / statistics & numerical data*
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnancy Complications, Infectious* / physiopathology
  • Pregnancy Outcome / epidemiology
  • Serologic Tests / methods
  • Severity of Illness Index