Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors

Chin J Nat Med. 2020 Oct;18(10):729-737. doi: 10.1016/S1875-5364(20)60013-9.

Abstract

A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC5074.0 ± 1.3 μmol·L-1) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.

Keywords: Enzyme assay; Molecular docking; Pyrano[2, 3-d]trizaole; α-Glucosidase inhibitor.

MeSH terms

  • Carbohydrates / chemistry*
  • Glycoside Hydrolase Inhibitors / chemistry*
  • Molecular Docking Simulation
  • Molecular Structure
  • Triazoles / chemistry*

Substances

  • Carbohydrates
  • Glycoside Hydrolase Inhibitors
  • Triazoles