MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease: New and Potential Therapeutic Targets

Lukasz Zareba; Alex Fitas; Marta Wolska; Eva Junger; Ceren Eyileten; Zofia Wicik; Salvatore De Rosa; Jolanta M Siller-Matula; Marek Postula

doi:10.1016/j.ccl.2020.07.005

MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease: New and Potential Therapeutic Targets

Cardiol Clin. 2020 Nov;38(4):601-617. doi: 10.1016/j.ccl.2020.07.005. Epub 2020 Sep 17.

Authors

Lukasz Zareba¹, Alex Fitas¹, Marta Wolska¹, Eva Junger¹, Ceren Eyileten¹, Zofia Wicik², Salvatore De Rosa³, Jolanta M Siller-Matula⁴, Marek Postula⁵

Affiliations

¹ Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland.
² Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland; Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Alameda da Universidade, s/n-Anchieta, São Paulo 09606-045, Brazil.
³ Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Viale Europa, Catanzaro 88100, Italy.
⁴ Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Spitalgasse 23, Vienna 1090, Austria.
⁵ Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland; Longevity Center, Warsaw, Poland. Electronic address: mpostula@wum.edu.pl.

PMID: 33036721
DOI: 10.1016/j.ccl.2020.07.005

Abstract

Noncoding RNAs (ncRNAs), including long noncoding RNAs and microRNAs, play an important role in coronary artery disease onset and progression. The ability of ncRNAs to simultaneously regulate many target genes allows them to modulate various key processes involved in atherosclerosis, including lipid metabolism, smooth muscle cell proliferation, autophagy, and foam cell formation. This review focuses on the therapeutic potential of the most important ncRNAs in coronary artery disease. Moreover, various other promising microRNAs and long noncoding RNAs that attract substantial scientific interest as potential therapeutic targets in coronary artery disease and merit further investigation are presented.

Keywords: Atherosclerosis; Long noncoding RNA; lncRNAs; miR-155; miR-33; miR-92a; miRNAs; microRNA.

Publication types

Review

MeSH terms

Coronary Artery Disease / genetics*
Coronary Artery Disease / metabolism
Coronary Artery Disease / therapy
Humans
Inflammation / genetics
Inflammation / prevention & control
MicroRNAs / metabolism*
RNA, Long Noncoding / metabolism*

Substances

MicroRNAs
RNA, Long Noncoding