MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia

Hansen J Kosasih; Nadia M Davidson; Stefan Bjelosevic; Emma Morrish; Margs S Brennan; Alicia Oshlack; Ricky W Johnstone; Gabriela Brumatti; Seong L Khaw; Paul G Ekert

doi:10.1182/bloodadvances.2020002708

MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia

Blood Adv. 2020 Oct 13;4(19):4918-4923. doi: 10.1182/bloodadvances.2020002708.

Authors

Hansen J Kosasih¹, Nadia M Davidson^{1

2

3}, Stefan Bjelosevic^{2

4}, Emma Morrish^{5

6}, Margs S Brennan^{5

6}, Alicia Oshlack^{2

4}, Ricky W Johnstone^{2

4}, Gabriela Brumatti^{5

6}, Seong L Khaw^{1

7}, Paul G Ekert^{1

2

8}

Affiliations

¹ Murdoch Children's Research Institute, Parkville, VIC, Australia.
² Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
³ School of BioSciences and.
⁴ The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
⁵ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
⁶ Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.
⁷ Royal Children's Hospital, Parkville, VIC, Australia; and.
⁸ Children's Cancer Institute Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.

Abstract

A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient.
MLL-TFE3 expression produces aggressive leukemia in a mouse model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*
Histone-Lysine N-Methyltransferase* / genetics
Humans
Infant
Leukemia*
Myeloid-Lymphoid Leukemia Protein* / genetics
Oncogene Proteins, Fusion / genetics*

Substances

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
KMT2A protein, human
Oncogene Proteins, Fusion
TFE3 protein, human
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase