A major obstacle in the introduction of nanoformulated drugs has been the fact that the shape of the drug delivery systems (DDSs) - the most important parameter driven by the nature of viruses and bacteria - remains almost out-of-scope in artificial systems. Here we propose a potential solution for this problem by developing a template-free approach for the formulation of hollow bacteria-like CaCO3-based pH-sensitive DDSs with controllable anisotropy and click-release behavior.