Background: Apelin (APLN), elabela (ELA), and nitric oxide (NO) have effects on physiological and behavioural properties in biological systems. This study was designed to determine APLN, ELA and NO levels in schizophrenia patients and assess whether these molecules are of diagnostic value.
Methods: A total of 33 schizophrenic patients and 32 ageand sex-adjusted healthy participants were included in the study. ELA, APLN and NO levels were measured using ELISA methods.
Results: Although the ELA and NO levels of the patients were lower than the control group, APLN levels were higher (p = 0.039, p = 0.019, p = 0.048, respectively). There was a significant negative correlation between APLN levels and triglyceride (TG) and body mass index (BMI) levels (r = -0.426, p = < 0.001 and r = -0.330, p = 0.007, respectively). Respectively, the areas under the receiver-operating characteristic (ROC) curves of the ELA/APLN, ELA/NO and APLN/NO ratios were 0.628, 0.590 and 0.709, 95% confident intervals (CI): 0.491-0.764, 0.450-0.730 and 0.579-0.840.
Conclusions: Decreased levels of ELA and NO and increased APLN levels in schizophrenia suggest that these molecules may be involved in its etiopathology. The APLN/NO ratio also seems to show promise in the diagnosis of the disease and may be used in future.
Uvod: Apelin (APLN), elabela (ELA), i azot oksid (NO) imaju efekte na fiziološke i bihevioralne osobine u biološkim sistemima. Ova studija je postavljena tako da odredi nivo APLN, ELA i NO kod pacijenata sa šizofrenijom i da proceni da li su ovi molekuli imaju dijagnostičku vrednost.
Metode: U studiju je uključeno ukupno 33 bolesnika sa šizofrenijom i 32 zdrava učesnika prilagođene starosti i pola. Nivoi ELA, APLN i NO su mereni korišćenjem ELISA metoda.
Rezultati: Iako su nivoi ELA i NO kod pacijenata bili niži nego kod kontrolne grupe, nivoi APLN bili su viši (p = 0,039, p = 0,019, p = 0,048). Došlo je do značajne negativne korelacije između nivoa APLN i nivoa triglicerida (TG) i indeksa telesne mase (BMI) (r = -0,426, p = < 0,001 i r = -0,330, p = 0,007, respektivno). Površine ispod ROC krive za ELA/APLN, ELA/NO i APLN/NO su bile 0,628, 0,590 i 0,709, respektivno, 95% intervali poverenja (CI): 0,491-0,764, 0,450-0,730 i 0,579-0,840.
Zaključak: Smanjeni nivoi ELA i NO i povećani nivo APLN kod šizofrenije ukazuju da ovi molekuli mogu biti u vezi sa njenom etiopatologijom. Izgleda da će odnos APLN/NO moći da se koristi u dijagnostici bolesti u budućnosti.
Keywords: apelin; elabela; nitric oxide; schizophrenia.
2020 Zekiye Catak, Hilal Kaya, Esra Kocdemir, Kader Ugur, Guzel Saadet Pilten, Meltem Yardim, Ibrahim Sahin, Agirbas Esra Piril, Suleyman Aydin, published by CEON/CEES.