Estriol in regulation of cell-mediated immune reactions in multiple sclerosis

Irina Nekrasova; Sergei Shirshev

doi:10.1016/j.jneuroim.2020.577421

Estriol in regulation of cell-mediated immune reactions in multiple sclerosis

J Neuroimmunol. 2020 Dec 15:349:577421. doi: 10.1016/j.jneuroim.2020.577421. Epub 2020 Sep 30.

Authors

Irina Nekrasova¹, Sergei Shirshev²

Affiliations

¹ Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva str., 13, 614081 Perm, Russia. Electronic address: nirina5@mail.ru.
² Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva str., 13, 614081 Perm, Russia.

PMID: 33032016
DOI: 10.1016/j.jneuroim.2020.577421

Abstract

The effect of pregnancy hormone estriol (E₃) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E₃ inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E₃ influence. At the same time, E₃ stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients. Thus, the MS amelioration during pregnancy may be related to E₃ influence.

Keywords: Estriol; Indoleamine-2,3-dioxygenase; Multiple sclerosis; Phagocytosis; Regulatory T cells.

MeSH terms

Adaptive Immunity / drug effects
Adaptive Immunity / immunology*
Adult
Cells, Cultured
Dose-Response Relationship, Drug
Estriol / pharmacology*
Female
Humans
Immunity, Cellular / drug effects
Immunity, Cellular / immunology*
Immunity, Innate / drug effects
Immunity, Innate / immunology*
Male
Multiple Sclerosis / blood
Multiple Sclerosis / immunology*

Substances

Estriol