A Designer Quest for the Achilles' Heel of Influenza

J Eduardo Fajardo; Andras Fiser

doi:10.1016/j.str.2020.09.004

A Designer Quest for the Achilles' Heel of Influenza

Structure. 2020 Oct 6;28(10):1083-1084. doi: 10.1016/j.str.2020.09.004.

Authors

J Eduardo Fajardo¹, Andras Fiser²

Affiliations

¹ Department of Systems and Computational Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA.
² Department of Systems and Computational Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA. Electronic address: andras.fiser@einsteinmed.org.

Abstract

Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antibodies, Monoclonal
Biophysical Phenomena
Humans
Influenza, Human* / diagnosis
Peptides, Cyclic

Substances

Antibodies, Monoclonal
Peptides, Cyclic

Abstract

Publication types

MeSH terms

Substances

Grants and funding