Decoding the role of zebrafish neuroglia in CNS disease modeling

Konstantin N Zabegalov; Dongmei Wang; LongEn Yang; Jingtao Wang; Guojun Hu; Nazar Serikuly; Erik T Alpyshov; Sergey L Khatsko; Aleksander Zhdanov; Konstantin A Demin; David S Galstyan; Andrey D Volgin; Murilo S de Abreu; Tatyana Strekalova; Cai Song; Tamara G Amstislavskaya; Yury Sysoev; Pavel E Musienko; Allan V Kalueff

doi:10.1016/j.brainresbull.2020.09.020

Decoding the role of zebrafish neuroglia in CNS disease modeling

Brain Res Bull. 2021 Jan:166:44-53. doi: 10.1016/j.brainresbull.2020.09.020. Epub 2020 Oct 4.

Authors

Konstantin N Zabegalov¹, Dongmei Wang², LongEn Yang², Jingtao Wang², Guojun Hu², Nazar Serikuly², Erik T Alpyshov², Sergey L Khatsko³, Aleksander Zhdanov³, Konstantin A Demin⁴, David S Galstyan⁵, Andrey D Volgin⁶, Murilo S de Abreu⁷, Tatyana Strekalova⁸, Cai Song⁹, Tamara G Amstislavskaya¹⁰, Yury Sysoev¹¹, Pavel E Musienko¹², Allan V Kalueff¹³

Affiliations

¹ School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia.
² School of Pharmacy, Southwest University, Chongqing, China.
³ Ural Federal University, Ekaterinburg, Russia.
⁴ Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁵ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
⁶ Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
⁷ Bioscience Institute, University of Passo Fundo, Passo Fundo, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia. Electronic address: abreu_murilo@hotmail.com.
⁸ Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; Division of Molecular Psychiatry, Centre of Mental Health, University of Würzburg, Würzburg, Germany.
⁹ Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China.
¹⁰ Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia; Zelman Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia.
¹¹ Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, Petersburg State University, St. Petersburg, Russia; Department of Pharmacology and Clinical Pharmacology, St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, Russia.
¹² Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, Petersburg State University, St. Petersburg, Russia; Institute of Phthisiopulmonology, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
¹³ School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

PMID: 33027679
DOI: 10.1016/j.brainresbull.2020.09.020

Abstract

Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.

Keywords: CNS disorders; Macroglia; Microglia; Neuroglia; Rodents; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Central Nervous System Diseases*
Disease Models, Animal*
Humans
Neuroglia*
Translational Research, Biomedical*
Zebrafish*