Abstract
Introduction:
The American Association for the Study of Liver Diseases recommends hepatitis D virus (HDV) screening in certain high-risk groups; however, the effectiveness is unknown.
Methods:
A study of North American patients with hepatitis B (HBV) referred to the NIH was performed to identify risk factors associated with HDV infection. Active HDV was "confirmed" by serum HDV RNA or histologic HDV antigen staining.
Results:
Six hundred fifty-two were studied, of which 91 were HDV "confirmed." Independent risk factors for HDV included: intravenous drug users, HBV-DNA <2,000 IU/mL, alanine aminotransferase >40 U/L, and HDV endemic country of origin.
Disussion:
North American patients with HBV and significant risk factors should be screened for HDV.
Copyright © 2020 by The American College of Gastroenterology.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Adult
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Alanine Transaminase / blood
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Alkaline Phosphatase / blood
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Aspartate Aminotransferases / blood
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Cohort Studies
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Coinfection
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DNA, Viral / blood*
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Emigrants and Immigrants
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Endemic Diseases
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Female
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Hepatitis Antibodies / blood
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Hepatitis B, Chronic / blood
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Hepatitis B, Chronic / epidemiology*
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Hepatitis D / blood
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Hepatitis D / diagnosis
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Hepatitis D / epidemiology*
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Hepatitis delta Antigens / blood
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Humans
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Male
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Mass Screening
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Middle Aged
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Platelet Count
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Prothrombin Time
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RNA, Viral / blood
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Retrospective Studies
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Risk Assessment
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Risk Factors
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Serum Albumin / metabolism
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Substance Abuse, Intravenous / epidemiology*
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United States / epidemiology
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Viral Load
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gamma-Glutamyltransferase / blood
Substances
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DNA, Viral
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Hepatitis Antibodies
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Hepatitis delta Antigens
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RNA, Viral
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Serum Albumin
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gamma-Glutamyltransferase
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase