Low immune response rate of HIV-infected patients to a single injection of hepatitis A vaccine

Infect Dis Now. 2021 Feb;51(1):94-96. doi: 10.1016/j.medmal.2020.09.016. Epub 2020 Oct 3.

Abstract

Objectives: We aimed to evaluate the immune response of HIV-1 positive patients to a single injection of HAV vaccine in a context of vaccine shortage during the 2017 European outbreak.

Methods: We retrospectively enrolled all HIV-1 positive patients vaccinated by a single injection of HAV vaccine Vaqta 50®. HAV serology was performed before and>30 days after the vaccine injection.

Results: Among the 73 patients, HIV-1 viral load was≤50 copies/mL in 93.2% of the cases. Medians of CD4 and median ratio of T CD4/CD8 cells were 658/mm3 and 0.9, respectively. A low immune response rate (59.7%) was observed among the patients. Responders had a significantly higher CD4/CD8 cell ratio than non-responders.

Conclusions: A serologic control should be recommended in this population in the event of a single injection vaccination schedule. During routine follow-up, and prior to any untoward event, physicians should assess the vaccination coverage of HIV-infected patients.

Keywords: Disease outbreak; HIV infection; Hepatitis A; Hepatitis A antibodies; Immune response; Vaccine.

MeSH terms

  • Adult
  • CD4 Lymphocyte Count / methods
  • CD4-CD8 Ratio / methods
  • Disease Outbreaks
  • HIV Infections / immunology*
  • Hepatitis A / epidemiology
  • Hepatitis A / immunology
  • Hepatitis A / prevention & control*
  • Hepatitis A Antibodies / blood
  • Hepatitis A Vaccines / administration & dosage
  • Hepatitis A Vaccines / immunology*
  • Humans
  • Immunity / immunology
  • Immunization Schedule
  • Middle Aged
  • Retrospective Studies
  • Viral Load

Substances

  • Hepatitis A Antibodies
  • Hepatitis A Vaccines