Gait analysis of a post induced traumatic spinal cord injury porcine model

Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul:2020:3803-3806. doi: 10.1109/EMBC44109.2020.9175280.

Abstract

Porcine model constitutes a potential translational model to study traumatic spinal cord injuries (TSCI) considering its recent use in numerous studies. Recovery of the animal is currently monitored through a qualitative evaluation of the gait. Adding a quantitative evaluation might help to better assess the functional recovery of the animal. In this study, a new controlled method involving the use of an electro-magnetic actuator was used on a pig to induce a TSCI. Chronic monitoring was done using a quantitative analysis of the gait. Results show both, the injury of the pig and its functional recovery. This large animal model will help to provide a better understanding of injury and recovery mechanisms and thus could constitute a strong preclinical model for future therapeutic studies.Clinical Relevance- Methodology and results from this study would provide a better insight on the functional recovery after traumatic spinal cord injuries.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Gait
  • Gait Analysis*
  • Recovery of Function
  • Spinal Cord Injuries*
  • Swine