Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis

Raphaëlle Bourgeois; Romain Devillers; Nicolas Perrot; Audrey-Anne Després; Marie-Chloé Boulanger; Patricia L Mitchell; Jakie Guertin; Patrick Couture; Michael B Boffa; Corey A Scipione; Philippe Pibarot; Marlys L Koschinsky; Patrick Mathieu; Benoit J Arsenault

doi:10.1016/j.jacbts.2020.06.012

Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis

JACC Basic Transl Sci. 2020 Aug 26;5(9):888-897. doi: 10.1016/j.jacbts.2020.06.012. eCollection 2020 Sep.

Authors

Raphaëlle Bourgeois^{1

2}, Romain Devillers^{1

3}, Nicolas Perrot^{1

2}, Audrey-Anne Després^{1

2}, Marie-Chloé Boulanger¹, Patricia L Mitchell¹, Jakie Guertin^{1

2}, Patrick Couture^{1

4}, Michael B Boffa⁵, Corey A Scipione⁵, Philippe Pibarot^{1

2}, Marlys L Koschinsky⁵, Patrick Mathieu^{1

3}, Benoit J Arsenault^{1

2}

Affiliations

¹ Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.
² Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.
³ Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada.
⁴ Centre de Recherche du CHU de Québec, Quebec, Canada.
⁵ Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Abstract

Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.

Keywords: ALR, adiponectin-to-leptin ratio; ATX, autotaxin; ATX-apo(a), ATX carried by Lp(a); ATX-apoB, ATX carried by apoB-containing lipoproteins; BMI, body mass index; CAD, coronary artery disease; CAVS, calcific aortic valve stenosis; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp(a), lipoprotein(a); LysoPA, lysophosphatidic acid; LysoPC, lysophosphatidylcholine; OxPLs, oxidized phospholipids; apo(a), apolipoprotein(a); apoB, apolipoprotein B; autotaxin; calcific aortic valve stenosis; lipoprotein(a); low-density lipoproteins; obesity.