Identifying Plant-Based Natural Medicine against Oxidative Stress and Neurodegenerative Disorders

Oxid Med Cell Longev. 2020 Sep 15:2020:8648742. doi: 10.1155/2020/8648742. eCollection 2020.

Abstract

Free radicals and oxidative stress are among the most studied factors leading to the imbalance in mental health. With no exception, free radicals also damage neuronal cells, leading to various degenerative diseases. With existing modern medications, around 80% of the world population relies on herbal medicine for various ailments. Phytochemicals in plants have a wide range of pharmacological properties, the major being their ability to scavenge free radicals. Plant polyphenols are among the major class of antioxidants identified in plants. This antioxidative property of plant compounds and their ability to downgrade the process of oxidative stress can be used to treat neurodegenerative diseases. However, selecting plants and their active compounds is a crucial step in framing the mechanism of action underlying their therapeutic potential.

Publication types

  • Review

MeSH terms

  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Humans
  • NADPH Oxidases / metabolism
  • NF-kappa B / metabolism
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / pathology
  • Oxidative Stress / drug effects*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plants, Medicinal / chemistry*
  • Plants, Medicinal / metabolism
  • Polyphenols / isolation & purification
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use
  • Reactive Oxygen Species / chemistry
  • Reactive Oxygen Species / metabolism

Substances

  • Antioxidants
  • NF-kappa B
  • Plant Extracts
  • Polyphenols
  • Reactive Oxygen Species
  • NADPH Oxidases