Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation

Front Immunol. 2020 Sep 11:11:2181. doi: 10.3389/fimmu.2020.02181. eCollection 2020.

Abstract

Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity of Bordetella pertussis adenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.

Keywords: Bordetella pertussis; adenylate cyclase toxin; dedifferentiation; macrophages; monocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenylate Cyclase Toxin / pharmacology
  • Adenylate Cyclase Toxin / physiology*
  • Animals
  • Antigen Presentation / drug effects
  • Bordetella pertussis / physiology*
  • Cell Dedifferentiation / drug effects
  • Cell Differentiation
  • Cyclic AMP / physiology
  • Host-Pathogen Interactions / immunology
  • Humans
  • Immunity, Innate / drug effects
  • Immunity, Mucosal / drug effects
  • Macrophages, Alveolar / cytology
  • Macrophages, Alveolar / drug effects*
  • Mice
  • Models, Biological
  • Monocytes / cytology
  • Monocytes / drug effects*
  • Phagocytosis
  • Respiratory System / drug effects
  • Respiratory System / immunology
  • Respiratory System / microbiology
  • Second Messenger Systems / drug effects
  • Second Messenger Systems / physiology

Substances

  • Adenylate Cyclase Toxin
  • Cyclic AMP