Different radioinducid tumors synchrony in an acute lymphoblastic leukemia survivor

Abstract

The cranial radiation-induced tumors appearance in pediatric patients treated for hematological diseases such as leukemia/T-lymphoblastic lymphoma (T-ALL/LBL) is a known phenomenon that may include lesions of different malignant degrees and require neurosurgical treatment. We present the case of a 38-year-old man referred to our department for a sudden diplopia with 6-month progressive left hemiparesis and frequent falls. After imaging tests, different intra and extraxial lesions with different radiological behavior were observed, performing a single surgical approach for their resection. The pathological anatomy confirms four histological variants: meningioma (grade 1 and 2 [atypical]), subependymoma, and cavernoma. We discuss the teratogenic role of ionizing radiation.

Keywords: Acute lymphoblastic leukemia; Brain tumor; Cranial radiation; Leucemia linfoblástica aguda; Radiación craneal; Radio-induced tumor; Radiocirugía; Radiosurgery; Subependimoma; Subependymoma; Tumor cerebral; Tumor radioinducido.