A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2

Signal Transduct Target Ther. 2020 Oct 3;5(1):218. doi: 10.1038/s41392-020-00343-z.

Authors

Zhe-Rui Zhang^#^{1

2}, Ya-Nan Zhang^#^{1

2}, Xiao-Dan Li^#^{1

3}, Hong-Qing Zhang^{1

2}, Shu-Qi Xiao¹, Fei Deng⁴, Zhi-Ming Yuan¹, Han-Qing Ye⁵, Bo Zhang⁶

Affiliations

¹ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
² University of Chinese Academy of Sciences, 100049, Beijing, China.
³ Hunan Normal University, School of Medicine, 410081, Changsha, China.
⁴ State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, Hubei, China.
⁵ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. yehq@wh.iov.cn.
⁶ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. zhangbo@wh.iov.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Betacoronavirus / drug effects*
Betacoronavirus / pathogenicity
Biological Products / chemistry
Biological Products / pharmacology
Bufanolides / chemistry
Bufanolides / pharmacology
COVID-19
Cardiac Glycosides / chemistry
Cardiac Glycosides / pharmacology*
Cell Survival / drug effects
Chlorocebus aethiops
Chloroquine / chemistry
Chloroquine / pharmacology
Coronavirus Infections / drug therapy
Coronavirus Infections / virology
Digoxin / chemistry
Digoxin / pharmacology
Gene Expression Regulation / drug effects*
High-Throughput Screening Assays
Host-Pathogen Interactions / drug effects*
Host-Pathogen Interactions / genetics
Humans
Janus Kinases / antagonists & inhibitors
Janus Kinases / genetics
Janus Kinases / metabolism
Mitogen-Activated Protein Kinases / antagonists & inhibitors
Mitogen-Activated Protein Kinases / genetics
Mitogen-Activated Protein Kinases / metabolism
NF-E2-Related Factor 2 / antagonists & inhibitors
NF-E2-Related Factor 2 / genetics
NF-E2-Related Factor 2 / metabolism
NF-kappa B / antagonists & inhibitors
NF-kappa B / genetics
NF-kappa B / metabolism
Pandemics
Phenanthrenes / chemistry
Phenanthrenes / pharmacology
Pneumonia, Viral / drug therapy
Pneumonia, Viral / virology
SARS-CoV-2
Signal Transduction
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase / genetics
Sodium-Potassium-Exchanging ATPase / metabolism
Vero Cells
Virus Replication / drug effects

Substances

Antiviral Agents
Biological Products
Bufanolides
Cardiac Glycosides
NF-E2-Related Factor 2
NF-kappa B
Phenanthrenes
cryptotanshinone
Digoxin
Chloroquine
Janus Kinases
Mitogen-Activated Protein Kinases
Sodium-Potassium-Exchanging ATPase
bufalin