Heterojunction formation between copper(II) oxide nanoparticles and single-walled carbon nanotubes to enhance antibacterial performance

Kamal Prasad Sapkota; Md Mehedi Hassan; Sita Shrestha; Md Abu Hanif; Md Akherul Islam; Jeasmin Akter; Hafiz Ghulam Abbas; Jae Ryang Hahn

doi:10.1016/j.ijpharm.2020.119937

Heterojunction formation between copper(II) oxide nanoparticles and single-walled carbon nanotubes to enhance antibacterial performance

Int J Pharm. 2020 Nov 30:590:119937. doi: 10.1016/j.ijpharm.2020.119937. Epub 2020 Oct 1.

Authors

Kamal Prasad Sapkota¹, Md Mehedi Hassan², Sita Shrestha³, Md Abu Hanif⁴, Md Akherul Islam⁴, Jeasmin Akter⁴, Hafiz Ghulam Abbas⁵, Jae Ryang Hahn⁶

Affiliations

¹ Department of Chemistry, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju 54896, South Korea; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44618, Nepal.
² Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University, Jeonju 54907, South Korea.
³ Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea.
⁴ Department of Chemistry, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju 54896, South Korea.
⁵ Department of Nanoscience and Nanotechnology, Jeonbuk National University, Jeonju 54896, South Korea.
⁶ Department of Chemistry, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju 54896, South Korea; Department of Nanoscience and Nanotechnology, Jeonbuk National University, Jeonju 54896, South Korea; Textile Engineering, Chemistry and Science, North Carolina State University, 2401 Research Dr., Raleigh, NC 27695-8301, USA.

PMID: 33011252
DOI: 10.1016/j.ijpharm.2020.119937

Abstract

We delineate the excellent bactericidal efficacy of stable heterojunction nanocomposites composed of single-walled carbon nanotubes (SWCNTs) and copper(II) oxide (CuO) synthesized via facile recrystallization and calcination. The bactericidal effectiveness of the fabricated nanocomposites was examined using the standard broth-dilution method and the growth-inhibition-zone analysis method, in which bacteria cultured in an incubator in tryptic soy broth medium were subjected to the prepared samples. The bactericidal activity of all of the as-synthesized samples is evident in both methods, displaying a substantial decrease in bacterial colonies and resulting in clear inhibition zones, respectively. Among the CuO-SWCNT nanocomposites, the sample subjected to calcination at 500 °C for 5 h was found to exhibit the best performance against Staphylococcus aureus and Escherichia coli, forming inhibition zones 182% and 162% larger than those formed by pure CuO, respectively.

Keywords: Antibacterial; Bactericidal; CuO-SWCNT nanostructures; Escherichia coli; Growth inhibition; Heterojunction; Staphylococcus aureus.

MeSH terms

Anti-Bacterial Agents / pharmacology
Copper
Nanoparticles*
Nanotubes, Carbon*
Oxides

Substances

Anti-Bacterial Agents
Nanotubes, Carbon
Oxides
Copper
cupric oxide