[Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection]

Mol Biol (Mosk). 2020 Sep-Oct;54(5):707-717. doi: 10.31857/S0026898420050031.
[Article in Russian]

Abstract

It is commonly known that the antiviral activity of the TRIM5α protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5α can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5a protein and the prospects for using it in gene therapy of HIV infection.

Keywords: HIV-1; TRIM5α; gene therapy.

Publication types

  • Review

MeSH terms

  • Antiviral Restriction Factors
  • Genetic Therapy*
  • HIV Infections* / genetics
  • HIV Infections* / therapy
  • Humans
  • Tripartite Motif Proteins / genetics*
  • Ubiquitin-Protein Ligases / genetics*

Substances

  • Antiviral Restriction Factors
  • Tripartite Motif Proteins
  • TRIM5 protein, human
  • Ubiquitin-Protein Ligases