Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

Wenguang Liu; Min Wang; Wei Cheng; Wen Niu; Mi Chen; Meng Luo; Chenxi Xie; Tongtong Leng; Long Zhang; Bo Lei

doi:10.1016/j.bioactmat.2020.09.008

Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

Bioact Mater. 2020 Sep 23;6(3):721-728. doi: 10.1016/j.bioactmat.2020.09.008. eCollection 2021 Mar.

Authors

Wenguang Liu¹, Min Wang¹, Wei Cheng¹, Wen Niu¹, Mi Chen¹, Meng Luo¹, Chenxi Xie¹, Tongtong Leng¹, Long Zhang¹, Bo Lei^{1

2

3

4}

Affiliations

¹ Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China.
² Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, China.
³ National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710000, China.
⁴ Instrument Analysis Center, Xi'an Jiaotong University, Xi'an, 710054, China.

Abstract

The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-ε-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.

Keywords: Anti-inflammation; Antibacterial; Bioactive dressing; Polycitrate; Wound healing.