COVID-19 and the kidney

Mohamed Hassanein; Yeshwanter Radhakrishnan; John Sedor; Tushar Vachharajani; Vidula T Vachharajani; Joshua Augustine; Sevag Demirjian; George Thomas

doi:10.3949/ccjm.87a.20072

COVID-19 and the kidney

Cleve Clin J Med. 2020 Oct 1;87(10):619-631. doi: 10.3949/ccjm.87a.20072.

Authors

Mohamed Hassanein¹, Yeshwanter Radhakrishnan², John Sedor³, Tushar Vachharajani⁴, Vidula T Vachharajani⁵, Joshua Augustine⁶, Sevag Demirjian⁷, George Thomas⁸

Affiliations

¹ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic.
² Cleveland Clinic Akron General, Akron, OH.
³ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁴ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic; Clinical Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁵ Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁶ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁷ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁸ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH thomasg3@ccf.org.

PMID: 33004323
DOI: 10.3949/ccjm.87a.20072

Abstract

COVID-19 is primarily considered a respiratory illness, but the kidney may be one of the targets of SARS-CoV-2 infection, since the virus enters cells through the angiotensin-converting enzyme 2 receptor, which is found in abundance in the kidney. Information on kidney involvement in COVID-19 is limited but is evolving rapidly. This article discusses the pathogenesis of acute kidney injury (AKI) in COVID-19, its optimal management, and the impact of COVID-19 on patients with chronic kidney disease, patients with end-stage kidney disease on dialysis, and kidney transplant recipients.

Publication types

Review

MeSH terms

Angiotensin-Converting Enzyme 2
Betacoronavirus / physiology*
COVID-19
Comorbidity
Coronavirus Infections* / epidemiology
Coronavirus Infections* / physiopathology
Coronavirus Infections* / virology
Cost of Illness*
Humans
Kidney Diseases* / classification
Kidney Diseases* / epidemiology
Kidney Diseases* / therapy
Kidney Diseases* / virology
Pandemics*
Patient Care Management / methods*
Peptidyl-Dipeptidase A / metabolism
Pneumonia, Viral* / epidemiology
Pneumonia, Viral* / physiopathology
Pneumonia, Viral* / virology
SARS-CoV-2

Substances

Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2