Abstract
Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to the LRR and PDZ (LAP) protein family first described twenty years ago. In this review, we will retrace the history of LAP family protein research and draw attention to their contribution in cancer by detailing the features of its members at the structural and functional levels, and highlighting their shared-but also different-implication in the tumoral process.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Amino Acid Sequence
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Animals
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Caenorhabditis elegans Proteins / genetics
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Disease Models, Animal
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Drosophila Proteins / genetics
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Neoplasms / pathology*
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Protein Domains / genetics
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Protein Interaction Maps
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Protein Processing, Post-Translational
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Sequence Homology, Amino Acid
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Sialoglycoproteins / genetics
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Sialoglycoproteins / metabolism*
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism*
Substances
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Adaptor Proteins, Signal Transducing
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Drosophila Proteins
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ERBIN protein, human
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LET-413 protein, C elegans
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LRRC1 protein, human
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LRRC7 protein, human
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Membrane Proteins
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SCRIB protein, human
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Scrib protein, Drosophila
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Sialoglycoproteins
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Tumor Suppressor Proteins