Next-generation Sequencing of Cerebrospinal Fluid: How Can a Liquid be Like a Solid?

Clin Cancer Res. 2020 Dec 1;26(23):6077-6079. doi: 10.1158/1078-0432.CCR-20-3330. Epub 2020 Sep 30.

Abstract

The APOLLO investigators showed that next-generation sequencing of cerebrospinal fluid can reveal molecular alterations-how should this affect our management approach?See related article by Xing et al., p. 6168.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acrylamides
  • Aniline Compounds
  • Biomarkers
  • Carcinoma, Non-Small-Cell Lung*
  • Central Nervous System
  • ErbB Receptors
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Lung Neoplasms*
  • Mutation
  • Protein Kinase Inhibitors

Substances

  • Acrylamides
  • Aniline Compounds
  • Biomarkers
  • Protein Kinase Inhibitors
  • osimertinib
  • EGFR protein, human
  • ErbB Receptors